EDK
Editome Disease Knowledgebase
Chronic Myeloid Leukemia
| Disease name | Chronic Myeloid Leukemia |
|---|---|
| Classfication | Cancer |
| Related Enzyme(s) | |
| EFO | EFO:0000339 |
| DOID | 8552 |
| OMIM | |
| NCI | |
| Definition | Chronic myelogenous leukemia (CML) is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-let-7a-1 | ADAR1 | 2 | A-to-I | MI0000060 | ADAR1 regulates let-7 miRNA biogenesis in an A-to-I editing dependent manner, it promotes the self-renewal and survival capability of chronic myeloid leukemia Leukemic stem cells. |
| Enzyme | Full Name | Location | Ensembl | Targets | Related Diseases | Aliases |
|---|---|---|---|---|---|---|
| ADAR1 | Adenosine deaminase, RNA specific | Chr1:154582057..154631560 |
|
|